Endocrine Abstracts

To elucidate the functional role of IGFBP-2 for in vivo skeletal muscle growth and function, skeletal muscle cellularity and metabolism as well as body growth and composition have been studied in a transgenic mouse model overexpressing IGFBP-2. Postnatal growth rate of transgenic mice (n=20) was clearly reduced from day 21 of age by 6–8% (P<0.05) compared with non-transgenic controls (n=37). At the final day of live (day 72 of age) body pro...

Cross-talk between adipose tissue and skeletal muscle via endocrine and paracrine mechanisms may be important in determining nutrient partitioning and lean-to-fat ratio. Such interactions could be mediated in part by adipokines secreted from adipose tissue. Little is known, however, about the role of adipokines in influencing growth and development of skeletal muscle.The aim of this study was to determine the direct effects of leptin and adiponectin on t...